Exhibit 8

Notification Procedures for Other Ocular Lesions

 Grading Item Letter? Suggested language Referral to ophthalmologist?
Central artery occlusion Consult with Retinal Reading Center ophthalmologist about occlusive processes. Possible outcomes are:

1) Retinal alert for fresh vein occlusion, or vein occlusion with associated macular edema.

2) Routine notification for old arteriolar or venous occlusion.

3) No letter for old occlusion of a very small branch.

Language as suggested by Reading Center ophthalmologist. Referral as suggested by Reading Center ophthalmologist.
Branch arteriole occlusion
Central vein occlusion
Branch vein occlusion
Hollenhorst plaque Routine notification for definite Hollenhorst plaque, and possibly for questionable Hollenhorst plaque. Consult with Reading Center ophthalmologist. Language as suggested by Reading Center ophthalmologist. None

Information may be of interest to primary care physician.

Asteroid hyalosis No letter.    
 

Large cup/disc ratio

No letter for questionable large cup/disc ratio (< 0.70).

Routine notification for definite large cup/disc ration of 0.70 with appearances such as undercutting.

 

 

Routine notification for cup/disc ratio > 0.80.

 

 

". . . the optic disc exhibits a moderately large cup-to-disc ratio of 0.70, which could indicate glaucoma."

Similar to above.

 

 

"Routine evaluation by an ophthalmologist may be advisable."

 

Same as above.

RH within disc margin Routine notification. ". . . exhibits a retinal hemorrhage on the optic disc. This is sometimes seen in eyes with glaucoma." "Routine evaluation by an ophthalmologist may be advisable."
Peripapillary atrophy No letter for most cases.

Consult the Reading Center ophthalmologist if unsure of significance, or if associated with angioid streaks.

 

 Language as suggested by Reading Center ophthalmologist.

 

 Referral as suggested by Reading Center ophthalmologist.

Other disc abnormality No letter for:

oblique insertion,

scleral crescent,

nerve head drusen,

minor vessel anomalies.

Possible letter for:

some vessel anomalies,

marked disc pallor.

Consult with the Reading Center ophthalmologist about severity of vessel anomalies or disc pallor, or other disc appearances of unknown significance.

 

 

 

 

 

 

 

 

 Language as suggested by Reading Center ophthalmologist.

 

 

 

 

 

 

 

 

 Referral as suggested by Reading Center ophthalmologist.

Glial/vitreous thickening No letter for:

glial tissue

small vitreous thickenings.

Consult the Reading Center ophthalmologist if any vitreous opacity suggests vitreous hemorrhage or an inflammatory reaction of the vitreous.

 

 

 

 Language as suggested by Reading Center ophthalmologist.

 

 

 

 Referral as suggested by Reading Center ophthalmologist.

Medullated nerve fibers No letter.    

 

 Cellophane reflex No letter.    

 

 Surface wrinkling retinopathy No letter if the surface wrinkling retinopathy encircles less than 180o of the macula, and the center of the macula is unaffected.

Routine notification if the surface wrinkling retinopathy fully encircles the macula, or if the macula is dragged or crossed by tension lines and vision may be affected.

 Consult the Reading Center ophthalmologist about borderline cases.

 

 

 ". . . exhibits mild retinal distortion due to an epiretinal membrane in the macular area (surface wrinkling retinopathy). "

 Similar to above.

 

 

 "The participant may be aware of this condition. If not, routine evaluation by an ophthalmologist may be advisable."

Similar to above.

Soft drusen

RPE depigmentation

Hyperpigmentation

No letter for most cases of early maculopathy.

Consult the Reading Center ophthalmologist regarding routine notification if extensive soft drusen are present, or if abnormalities involve the center of the macula and may affect vision.

Hyperpigmentation associated with POHS, fundus flavimaculatus other degenerative processes, or possible inflammatory processes may require routine notification. Consult with the Reading Center ophthalmologist.

 

 

Language as suggested by Reading Center ophthalmologist.

 

Language as suggested by Reading Center ophthalmologist.

 

 

 

Referral as suggested by Reading Center ophthalmologist.

Referral as suggested by Reading Center ophthalmologist.

SSR detachment

Subretinal hemorrhage

Subretinal fibrosis

Geographic atrophy

Consult the Reading Center ophthalmologist regarding notification for all end-stage maculopathy. Language as suggested by Reading Center ophthalmologist. Referral as suggested by Reading Center ophthalmologist.
Chorioretinal scar No letter for most small, peripheral chorioretinal scars.

Notification for:

1) Toxoplasmosis scars, or other large scars suggesting an old inflammatory process.

2) Chorioretinal scars involving the macula, affecting vision.

3) POHS, as suggested by any two of the following appearances:

a) round, "punched out" chorioretinal scars in the periphery,

b) chorioretinal scars in the macular area,

c) scarring around the optic disc.

 

 

 

Language as suggested by Reading Center ophthalmologist.

 

 

 

Referral as suggested by Reading Center ophthalmologist.

Nevus No letter for a nevus which appears flat, and has even pigmentation and regular or diffuse margins.

Routine notification for a nevus which may be elevated, or has uneven pigmentation and/or irregular margins. Possible notification if only a small portion of what is clearly a larger lesion extends into the photographic field. Consult Reading Center ophthalmologist.

 

 

 

Language as suggested by Reading Center ophthalmologist.

 

 

 

Referral as suggested by Reading Center ophthalmologist.

Retinal detachment Consult Reading Center ophthalmologist regarding retinal alert or routine notification. Language as suggested by Reading Center ophthalmologist. Referral as suggested by Reading Center ophthalmologist.
Other Other conditions which may require notification:

macular hole

choroidal folds

angioid streaks

fundus flavimaculatus

POHS (see description under chorioretinal scars).

 

Language as suggested by Reading Center ophthalmologist.

Referral as suggested by Reading Center ophthalmologist.

 

 

 Return to Light Box Grading Protocol

 

2/17/98